Research Paper Volume 10, Issue 12 pp 3683—3701

A functional variant of SMAD4 enhances macrophage recruitment and inflammatory response via TGF-β signal activation in Thoracic aortic aneurysm and dissection

Figure 4. rs12455792 C>T variant promotes MØ infiltration in human thoracic aorta specimens. (A) Representative confocal-microscopy graphs of immunostaining for CD86 in specimens from thoracic aortic aneurysm patients with rs12455792 CC, CT or TT genotypes. Red: CD68; Blue: DAPI. (B) The quantitative analysis of MØ cell numbers in different groups, n=8/group. Data are means ± SD. **P<0.01, ns: not significant. Scale bar: 100μm.