Research Paper Volume 10, Issue 12 pp 3683—3701

A functional variant of SMAD4 enhances macrophage recruitment and inflammatory response via TGF-β signal activation in Thoracic aortic aneurysm and dissection

Figure 5. rs12455792 C>T variant enhances TNF-α but not CD206 expression in human thoracic aorta specimens. (A) Immunofluorescence staining for TNF-α and CD206 in specimens from thoracic aortic aneurysm patients with rs12455792 CC, CT or TT genotypes. Red: TNF-α; Green: CD206; Blue: DAPI. (B) The plot of average integral optical density for TNF-α and CD206 expression in different groups, n=8/group. Data are means ± SD. *P<0.05, **P<0.01, ns: not significant. Scale bar: 100μm.