Research Paper Volume 10, Issue 12 pp 3683—3701

A functional variant of SMAD4 enhances macrophage recruitment and inflammatory response via TGF-β signal activation in Thoracic aortic aneurysm and dissection

Figure 7. Repression of SMAD4 leads to dilatation of both thoracic aorta and abdominal aorta. (A) Representative holistic view of Wild Type and SMAD4 KD mice under ultraviolet. The red fluorescence is observed in the naked skin of SMAD4 KD mice. (B) The polygram for time-dependent aorta dilatation in different groups; (C) The quantitative analysis for diameter of aortas among different groups at 4W after modeling; (D) Representative echocardiography images of aorta diameter in Wild Type and SMAD4 KD group at 2W or 4W, n=5/group. *: P<0.05. The data were presented as mean ± SD.