Research Paper Volume 10, Issue 12 pp 3683—3701

A functional variant of SMAD4 enhances macrophage recruitment and inflammatory response via TGF-β signal activation in Thoracic aortic aneurysm and dissection

Figure 9. Schematic diagram for the potential role of rs12455792 variant in pathological progression of TAAD. rs12455792 C>T variant might suppress SMAD4 expression by affecting the binding of transcription factors to the promoter of this gene, thus activate TGF-β signaling and chemotactic factors production, and further facilitate the MØ recruitment, vessel remodeling and pathological progression of TAAD.