Research Paper Volume 10, Issue 12 pp 3761—3773

DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation

Figure 2. Cumulus cells have longer telomeres than white blood cells. Comparison of average relative telomere length of all study subjects indicates that ovarian cells present longer telomeres than white blood cells (t(138)=-14.46, p<0.0001). Tissues are indicated with symbols. Study groups are indicated with colors. A= <35 years old and good responder (≥15 mature follicles), B= <35 years old and poor responder (≤5 mature follicles), C= >40 years old and poor responder (≤4 mature follicles) and D= >40 years old and good responder (≥12 mature follicles). Average relative TL is reported as Average dCT values, which are inversely proportional to actual TL. Therefore, higher average dCTs indicate shorter telomeres.