Research Paper Volume 10, Issue 12 pp 3774—3793

A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer

Figure 1. miR-433 was downregulated in CRC specimens and cell lines and correlated with signaling pathway associated with CRC progression. (a) The relative expression ratio of miR-433 in 35 paired fresh CRC and adjacent normal mucosa specimens (T, tumor; N, adjacent normal mucosa). (b) miR-433 was significantly underexpressed in CRC than adjacent normal mucosa by qRT-PCR (miR-433 referenced to U6). (c) The expression of miR-433 in several CRC cell lines. (d) The signaling pathways connected with miR-433 were mined in the miRWalk 3.0 database. (e) A survival curve relative to miR-433 expression median in CRC was plotted using the LinkedOmics database. *, p<0.05; **, p<0.01; ***, p<0.001.