Research Paper Volume 10, Issue 12 pp 3794—3805

Sevoflurane impairs learning and memory of the developing brain through post-transcriptional inhibition of CCNA2 via microRNA-19-3p

Figure 1. SEVO impairs learning, memory and neuron proliferation of neonatal rats. Neonatal rats were separated into 2 groups of ten of each. The control group (CTL) was exposed to normal gas and the SEVO group was exposed to 5% SEVO for 4 hours. (A-B) Morris water maze test. (A) Escape latency. (B) Path length. (C-D) PM-DAT at 6 weeks after SEVO exposure. (C) Time spent in aversive arm at training period. (D) Time spent in open arm at testing period. (E) Western blotting for BDNF in rat brain. (F-G) Ki-67 staining in the hippocampal area of rat brain, 6 weeks after SEVO exposure, by representative images (F), and by quantification (G). *p<0.05. N=10. Scale bars are 100µm.