Research Paper Volume 10, Issue 12 pp 3881—3896

Accelerated aging induced by deficiency of Zmpste24 protects old mice to develop bleomycin-induced pulmonary fibrosis

Figure 6. Microarray analysis of bleomycin-injured lungs of old Zmpste24 deficient mice (n=3) compared with old wildtype littermates (n=3). Lungs were obtained 21 days after bleomycin injury. (A) Volcano plot of the global gene expression profiling in lungs from old injured Zmpste24 deficient mice vs old WT mice. Each point represents the difference in expression (log fold-change) between the two groups of mice plotted against the level of statistical significance. Right blue dots represent overexpressed genes; left blue dots represent relatively downregulated genes at a significant level of p< 0.05. (B and C) Gene ontology (B) and KEGG (C) functional analysis. The most significant 20 terms are shown. Threshold criteria considered for the analysis are log fold-change > 1 or <-1 and p-value < 0.05 for genes, and >0.5 or z-0.5 for miRnas.