Research Paper Volume 10, Issue 12 pp 3986—3999

Injury factors alter miRNAs profiles of exosomes derived from islets and circulation

Figure 5. Expression of screened miRNAs in serum exosomes of STZ treated mice. Serum was sampled from ICR mice at different time after STZ injection. Fasting tail blood glucose (A) and serum insulin (B) levels were measured. The expression of 4 serum exosomal miRNAs selected from microarray miR-375-3p (C), miR-129-5p (D), miR-378a-3p (E), miR-382-5p (F) were analyzed using qRT-PCR. Values represent means ± SEM (n≥9 mice of each time point). (* P<0.05, ** P<0.01, *** P<0.001 compared with sodium citrate vehicles).