Research Paper Volume 10, Issue 12 pp 3986—3999

Injury factors alter miRNAs profiles of exosomes derived from islets and circulation

Figure 6. Serum exosomal miRNA-375 and miRNA-129 expression in T1DM and T2DM patients with different β cell function. After standard mixed meal tolerance tests, the area under curve (AUC) of plasma glucose were measured (A), and the ratio of C-peptide AUC to glucose AUC were calculated to evaluate islet β cell function (B). Serum exosomal miRNA-375 (E, F) and miRNA-129 (G, H) expression in T1DM and T2DM patients with diverse diabetes course were detected by qRT-PCR. All measurements are mean ± SEM (n≥10 subjects of each group) (* P<0.05, ** P<0.01, *** P<0.001 compared with NGT.)