Research Paper Volume 10, Issue 12 pp 4024—4041

SNCA overexpression disturbs hippocampal gene expression trajectories in midlife

Figure 4. Age-SNCA-dependent expression changes in mouse resembled age- and PD-dependent expression signatures in human. (A) Venn diagram comparing 2162 age-SNCA-regulated DEGs (see Fig. 3B) with a cross-species age signature gene set [14]. (B) Left panel shows WT12SE/WT6SE and TG12SE/WT12SE expression changes for 29 DEGs grouped by their class assignment that overlap with an age signature gene set (see A). Right heatmap reflects age-related expression changes in human brain as well as in mouse and rat hippocampus [14]. Greyed-out cells: no information. (C) Venn diagram comparing 2162 age-SNCA-regulated DEGs (see Fig. 3B) with genes known to change expression with respect to both age and PD in human [21]. (D) Left panel shows WT12SE/WT6SE and TG12SE/WT12SE expression changes for 19 DEGs grouped by their class assignment that overlap with the age-PD signature gene set (see C) [21]. Right panel indicates whether age- and PD-dependent expression changes in human are similar or opposite in direction [21].