Research Paper Volume 10, Issue 12 pp 4024—4041

SNCA overexpression disturbs hippocampal gene expression trajectories in midlife

Figure 6. Graphical summary. In standard environmental conditions, SNCA overexpression in TG mice (TGSE) imbalances the hippocampal transcriptome and interferes with gene expression adaptations in midlife so that some cellular processes become accelerated, while others fail to adapt age-adequately in comparison to WT animals (WTSE). Provision of environmental enrichment to TG animals (TGEE) prevents and counter-balances these disturbances so that a near-normal system state can be maintained despite persistent SNCA overexpression.