Research Paper Volume 10, Issue 12 pp 4120—4140

Overexpression of FoxM1 predicts poor prognosis of intrahepatic cholangiocarcinoma

Figure 5. Overexpression of FoxM1 promoted ICC progression in vivo. Representative images of nude mouse ICC hepatic xenograft models (red arrow head show primary xenografted tumor, while the yellow arrow indicates metastasis in (B-a, B-b and C-a, C-b) and HE-stained sections (A-c, B-c, C-c, and D-c: magnification × 40; A-d, B-d, C-d, and D-d: magnification × 400). The total number of tumor nodules/animal (E, G) and liver weight (g)/animal (F, H) of the hepatic xenograft tumors showed marked differences between the experimental and control groups (n = 5 per group). Statistics are shown with a bar graph. **P < 0.01, ***P < 0.001, ****P < 0.0001.