Research Paper Volume 10, Issue 12 pp 4152—4165

Mechanistic insight into hyaluronic acid and platelet-rich plasma-mediated anti-inflammatory and anti-apoptotic activities in osteoarthritic mice

Figure 4. Effects of HA+PRP on oxidative stress in chondrocytes. (A) ROS and (B) antioxidant levels of chondrocytes were recorded after treatment of IL-1β+TNF-α (I+T) conditioned medium in the presence of HA, PRP, and HA+PRP. *p<0.05, **p<0.01, ***p<0.001, compared with the value in cells cultured in I+T using student t-test. The results are presented as mean ± S.D. for 15 independent experimental replicates.