Figure 3. Effect of exercise training on APK associated cellular homeostasis. (A) Representative Western blots showing modulation in the levels of p-FOXO1, FOXO3a, p-FOXO3a, p-AMPKα1, AMPKα1, SIRT1, PGC-1α, PPARα, and SOD-1 extracted from the left ventricles of excised hearts. The α-tubulin was used as an internal control. (B) Densitometric analysis showing relative changes in protein levels represented by mean values ± SEM. *P< 0.05, **P< 0.01, ***P< 0.001signiﬁcant differences with respect to control group. #P<0.05, ##P<0.01, ###P< 0.001 signiﬁcant differences with respect to aging group.