Review Volume 10, Issue 12 pp 4269—4288

Protein synthesis and quality control in aging

Figure 3. Molecular pathways modulating lifespan via control of the translation machinery. Components of the Ras/MEK/ERK signaling pathway are shown in yellow, those of the PI3K/Akt/mTOR axis in green, the ISR pathway in yellow, and the translation machinery components in grey [80,166,175,180].