Figure 2. Daily food intake throughout the experiment. Grouped histograms depicting the mean daily food intake per group in C26 tumor-bearing (TB) male CD2F1 mice with ad libitum access to chow (dietary reference intake [DRI], n = 10); C26 TB mice on a 30% caloric restriction (CR, n = 10) diet; non-tumor bearing (NTB) mice with matched intake (MI, n= 10); NTB mice on a 30% caloric restriction (n = 10). The vertical bars indicate daily measurements of food intake, ranging from day 0 to 35, for each specified group. Food intake is expressed as grams (g). Food intake of C26 TB DRI mice decreased in the final days preceding sacrifice from 3.8 g to 2.9 g (p = 0.0002, paired-sample t-test). Consequently, food intake decreased in the other groups accordingly.