Research Paper Volume 10, Issue 12 pp 4213—4223

Caloric restriction is associated with preservation of muscle strength in experimental cancer cachexia

Figure 4. Body weight, muscle weight and tumor mass at sacrifice. Bar graphs depicting the mean ± SEM for (A) final bodyweight normalized to starting bodyweight, (B) tumor weight, (C) gastrocnemius muscle weight and (D) tibialis anterior muscle weight in C26 tumor-bearing (TB) male CD2F1 mice with ad libitum access to chow (dietary reference intake [DRI], n = 10); C26 TB mice on a 30% caloric restriction (CR, n = 10) diet; non-tumor bearing (NTB) mice with matched intake (MI, n = 10); NTB mice on a 30% caloric restriction (n = 10). Multiple group comparisons were done by one-way ANOVA with a Bonferroni’s post hoc test. All groups were compared against TB – DRI mice. Asterisk brackets are displayed for significant results only. * p < 0.05 ** p < 0.01 *** p < 0.001. Statistical comparison between TB DRI and TB 30% CR mice in tumor weight was done by Student’s t-test (p = 0.17).