Figure 5. The changes in the CARE index correlated with the changes in cognitive performance and other clinical variables measured between baseline and the three-year follow up in MCI subjects from the NADS dataset. Notes: 1) In each of these scatter diagrams, there is a significant correlation between changes in the CARE index and changes in the cognitive performance or clinical measures (p < 0.05, FDR corrected). 2) In Figure 4, the total number of subjects selected at baseline is equivalent of those at the three-year follow-up from the NADS dataset (MCI, 44 subjects). All subjects at the three-year follow-up had at least one resting-state functional connectivity MRI scan with a corresponding anatomical scan and had scores on the MMSE and AVLT. Abbreviations: NADS, Nanjing Aging and Dementia Study; MCI, mild cognitive impairment; CARE, characterizing AD risk event; EM, episodic memory; IPS, information processing speed; VF, visuospatial function; MMSE, Mini-Mental State Examination. A statistical threshold was set at a p < 0.05 (false discovery rate [FDR]-corrected]. Δ represents the changes.