Research Paper Volume 11, Issue 8 pp 2185—2201

Predicting progression from mild cognitive impairment to Alzheimer’s disease on an individual subject basis by applying the CARE index across different independent cohorts

Figure 5. The changes in the CARE index correlated with the changes in cognitive performance and other clinical variables measured between baseline and the three-year follow up in MCI subjects from the NADS dataset. Notes: 1) In each of these scatter diagrams, there is a significant correlation between changes in the CARE index and changes in the cognitive performance or clinical measures (p < 0.05, FDR corrected). 2) In Figure 4, the total number of subjects selected at baseline is equivalent of those at the three-year follow-up from the NADS dataset (MCI, 44 subjects). All subjects at the three-year follow-up had at least one resting-state functional connectivity MRI scan with a corresponding anatomical scan and had scores on the MMSE and AVLT. Abbreviations: NADS, Nanjing Aging and Dementia Study; MCI, mild cognitive impairment; CARE, characterizing AD risk event; EM, episodic memory; IPS, information processing speed; VF, visuospatial function; MMSE, Mini-Mental State Examination. A statistical threshold was set at a p < 0.05 (false discovery rate [FDR]-corrected]. Δ represents the changes.