Figure 6. Effect of CA3 α-synuclein knockdown on the glutamate receptors and synaptic expressions in the hippocampus. (A and B) LV- α-synuclein shRNA or control shRNA virus was stereotaxically injected in the hippocampal CA3 region, and the effect of α-synuclein knockdown on the glutamate receptors and synaptic expressions in the hippocampus was determined by Western blotting. © Double staining of α-synuclein with PSD-95 in the hippocampal CA3 was shown. n = 10 per group. Scale bar, 80 μm. (D) Schematic model for Rb1-mediated improvement of cognitive deficits in the MPTP mouse model of PD. Western blotting results are from three of the nine mice in each group and are expressed as the mean ± SEM of three experiments. **p < 0.01 vs. control shRNA group. Statistical significance was determined by one-way ANOVA and Bonferroni tests as post hoc comparisons.