Research Paper Volume 11, Issue 7 pp 1934—1964

Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway

Figure 7. Effect of Rb1 treatment on the glutamate receptors and synaptic expressions in the hippocampus in normal mice. (AD) Morris water maze tests were conducted after treatment with Rb1 (10 mg/kg or 40 mg/kg) in normal mice. Mice were analyzed for (A) the escape latency during a 5-day training course. In the probe tests, mice were analyzed (B) for the escape latency, (C) the time spent in the target zone, and (D) the target crossing to reach the target platform from the entrance. n = 8 per group. (E and F) Effects of Rb1 on the glutamate receptors and synaptic proteins expressions in the hippocampus in normal mice. Western blotting results are from two of the six mice in each group and are expressed as the mean ± SEM of three experiments. Statistical significance was determined by one-way ANOVA and Bonferroni tests as post hoc comparisons.