Research Paper Volume 11, Issue 7 pp 1990—2002

Hepatic lipid droplet breakdown through lipolysis during hibernation in Chinese Soft-Shelled Turtle (Pelodiscus sinensis)

Figure 6. Schematic diagram of LD breakdown during hibernation in the liver of Chinese Soft-Shelled Turtle (Pelodiscus sinensis). Entering hibernation, activated cAMP/PKA signals in the liver recruit ATGL to the surface of the LDs. Meanwhile, phosphorylation of perilipin-5 on the LD surface promotes the CGI-58-mediated induction of ATGL via the interaction between CGI-58 and ATGL. Ultimately, FAs hydrolyzed from TGs stored in LDs are transported into mitochondria for β-oxidation, thereby maintaining energy hemostasis in the body.