Research Paper Volume 11, Issue 7 pp 2071—2081

Early-life vancomycin treatment promotes airway inflammation and impairs microbiome homeostasis

Figure 1. Vancomycin use in perinatal and early life exacerbated allergic airway inflammation. (A) Representative time course for the vancomycin procedure involved the murine asthma model. (B, C) Total cell count and cell differentiation of inflammation cells in BALF. (D) The percentage of eosinophils in BALF quantified by Wright-Giemsa staining (Radnor, PA, USA). (E, F) IL-13 and IL-4 relative mRNA expression in lung tissue was measured by Q-PCR. Data are shown as means ± SEM with 10 samples per group. (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).