Research Paper Volume 11, Issue 7 pp 2098—2110

In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated

Figure 4. Correlations between GM parameters (μ0 and γ) derived from the survival curves of: (i) control mice used in IGF1 signaling experiments performed in different labs (see references to Figure 5), (ii) female mice bread at Jackson Laboratories, and (iii) several samples of female 129/Sv mice bread at authors’ laboratory [20]. The cross (Holz) in the upper left corner highlights the point related to female 129/Sv mice studied by Holzenberger et al. [12] and confirms the general consistency of the female 129/Sv trend, which is shown with gray round markers.