**Figure 5.** **Distributions of the variability measures (Δvar) obtained using a combination of continuous and grouped approaches with regression and SVA-correction for the individual pathways in KEGG database.** The distribution of the variability measures (Δvar) for the genes within each pathway is represented as a box, encapsulating part of the distribution between 1^{st} and 3^{rd} quantile, median of the box is colored in black. (**A**) represents variability measure distributions for the continuous, while (**B**) for the grouped approaches. Pathways on Y-axis and corresponding them boxes are ordered by increasing median. Boxes are colored in orange if the corresponding pathways have median Δvar > 0, and in blue, if median Δvar < 0. Text label on the plot shows percentage of pathways with median Δvar > 0. Red dashed line marks Δvar = 0, while black straight-line marks median across all the pathways. The mean values for the median across all pathways are 0.033 for Δvar(ρ)_{regression}, 0.021 for Δvar(ρ)_{SVA}, 0.033 for Δvar(IQR)_{regression}, and 0.027 for Δvar(IQR)_{SVA}.