Review Volume 11, Issue 8 pp 2488—2511

A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair

Figure 2. (A) Structural domains of the 53BP1 protein and its interaction partners (partially adapted from [101]). (B) Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (γH2AX); (adapted from PDB protein database, authors: Day M., Oliver, A.W., Pearl, L.H. (C) Structure of tandem Tudor domains ( [107];). (D) A tandem Tudor domain of the 53BP1 protein in complex with H4K20me2 ( [100];). (E) Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant (; author: Wan et al., to be published). The structural data in panels B-E were derived from the Protein Data Bank (PDB).