Review Volume 11, Issue 8 pp 2488—2511

A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair

Figure 3. A schematic illustration of the functions of the H4K20me2/me3-53BP1-RIF1-PTIP and BRCA1-CtIP protein complexes in the G1 and G2 phases of the cell cycle. DSB sites are depicted by red frames. The G1 phase is shown in red, the S phase is shown in yellow-orange (dashed blue in histogram from flow cytometry), and the G2 phase is shown in green (see the circular graph).