Review Volume 11, Issue 8 pp 2488—2511

A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair

Figure 7. The nuclear distribution pattern of A-type lamins (green) in 53BP1-positive DNA repair foci (red). (A) Spontaneously occurring DNA lesions in HeLa cells are shown, and (B) magnification is delineated by white arrows. Although A-type lamins do not directly accumulate at DNA lesions, (C) lamin A/C positivity in spontaneous DNA lesions could be essential for the stability of these 53BP1-positive foci and their error-free repair (refer to primary data and methodology in [155,156]). Scale bars, 0.5 µm.