Review Volume 11, Issue 8 pp 2512—2540

Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging

Figure 1. Impaired ribosome biogenesis. Impairment of multiple ribosome biogenesis stages (in bold black) activate p53 via the RPL5/RPL11/5S rRNA/Mdm2 pathway and is associated with various ribosomopathies (in red) TCS (Treacher Collins syndrome), DC (dyskeratosis congenital), SDS (Shwachman-Diamond syndrome), DBA (Diamond-Blackfan anemia) 5q- (5q- syndrome).