Research Paper Volume 11, Issue 8 pp 2430—2446

HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif

Figure 2. 3’UTR-longer genes do not affect their own expressions. (A) 3’UL genes without direct downregulation expression predominate. Only 6.89% of 3’UL genes show direct down-regulated downstream expression. The downregulation was defined as Spearman Rho < -0.3 and P-value < 0.05. (B) 3’UL genes without down-regulated gene expression control more aspects of molecular functions (hypergeometric test, retrieved from Molecular Signature Database). RNA-binding ranks highest in the function enrichment computation.