Research Paper Volume 11, Issue 8 pp 2457—2476

Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice

Figure 1. Conditional Tbk1-NKO mouse generation and genotyping. (A) Tbk1-NKO mice were established by crossing Tbk1fl/fl mice with Nestin-cre mice, and genotyped by PCR. (B) Western blot expression of Tbk1 in the cortex (co), cerebellum (cb), and liver (li). (C) Tbk1 immunohistochemistry in brain cortex. Bar = 20 μm.