Research Paper Volume 11, Issue 8 pp 2457—2476

Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice

Figure 4. Dendro-synaptic alterations induced by Tkb1 deficiency. (A) NF and MAP2 immunofluorescence was used to visualize dendrites. (B) Golgi-Cox brain staining in Tbk1-NKO and WT mice (n = 3). (C) Analysis of dendritic spine density (n = 10). *P < 0.05, compared to WT mice. (DE) Cortical synapse numbers, quantified from electron microscopy images (n = 6-7). *P < 0.05, compared to WT. Synapses are indicated by white arrows. Bar = 1 μm.