Research Paper Volume 11, Issue 8 pp 2457—2476

Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice

Figure 6. Astroglial alterations induced by Tkb1 deficiency. (A) GFAP immunostaining of the cerebellum of 5 and 14 months old mice (n = 3). Bar = 50 μm. Spheroidal astrocytes are indicated by arrows. (B) Quantification of astrocyte degeneration (n = 9); ***P < 0.001, compared to WT mice. (C) Double GFAP and p62 immunofluorescence of the cerebellum. Bar = 10 μm.