Research Paper Volume 11, Issue 8 pp 2477—2487

EPO enhances the protective effects of MSCs in experimental hyperoxia-induced neonatal mice by promoting angiogenesis

Figure 1. Effect of MSCs+EPO on body weight and lung injury. Experimental animals were continuously exposed to high oxygen environment for14 days to established BPD mode. MSCs and EPO were injected at 1h before and 7d after high oxygen exposure. (A) The average body weight was measured at 3-,7- and 14- day post-operation in each group. (B) Lung histopathology was detected by H&E staining(×100 magnification). (C) A morphometric analysis was conducted using performing radial alveolar counts (RAC) and, (D) A morphometric analysis of the alveolar septum thickness. Data are presented as the mean ± SD. *P < 0.05 compared with the control group; #P < 0.05 compared with the BPD group; P<0.05 compared with the EPO; P<0.05 compared with the MSCs group.