Figure 3. CA-30 restored the secretion of endocrine hormones in SMAP8 mice. Concentrations of corticotropin-releasing hormone (CRH) (A), gonadotropin-releasing hormone (GnRH) (B), luteinizing hormone (LH) (C), testosterone (T) (D), thyrotropic hormone-releasing hormone (TSH) (E), growth hormone (GH) (F) in mice, and the concentration ratio of T and estradiol (E2) (G). *P<0.05, **P<0.01, ***P<0.001, versus the SAMR1 mice, #P<0.05, ##P<0.01, ###P<0.001, versus the SAMP8 mice by unpaired Student's t-tests. All values are means ± S.D. n=9-11.