Research Paper Volume 11, Issue 11 pp 3463—3486

CA-30, an oligosaccharide fraction derived from Liuwei Dihuang decoction, ameliorates cognitive deterioration via the intestinal microbiome in the senescence-accelerated mouse prone 8 strain

Figure 5. CA-30 regulated abnormal cytokine secretion in SAMP8 mice. Concentrations (pg/mL) of interferon-γ (IFN-γ) (A), tumor necrosis factor α (TNF-α) (B), interleukin-4 (IL-4) (C) and interleukin-5 (IL-5) (D) in the blood plasma of mice were detected using Luminex® X-MAP® technology. Principal component analysis (PCA) of cytokine secretion of mice (E), with each point representing one mouse. PCA conducted with SAS 9.2 statistics package, with significance set at P < 0.05. Average PCA scores (F). *P<0.05, **P<0.01, ***P<0.001, versus the SAMR1 mice, #P<0.05, ##P<0.01, ###P<0.001, versus SAMP8 mice by unpaired Student's t-tests. All values are means ± S.D. n=9-11.