Research Paper Volume 11, Issue 11 pp 3487—3504

Investigation of bidirectional longitudinal associations between advanced epigenetic age and peripheral biomarkers of inflammation and metabolic syndrome

Figure 1. The Figure shows the results of cross-lagged models examining longitudinal associations between Hannum DNAm age residuals and metabolic syndrome (MetS) severity factor scores (A), and Lipids/Obesity factor scores (B). Measures of each marker were residualized on age and sex (applicable to A and B). (***p < 0.005, **p < 0.01, **p < 0.05).