Research Paper Volume 11, Issue 11 pp 3536—3550

E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis

Figure 6. Proposed model of this study. Brief schematic diagram of the interplay between TRIM6 and MI/R injury. TRIM6 induces the activation of IKKε through K48-linked polyubiquitination and further activates p-STAT1, thus promoting myocardial apoptosis and MI/R injury, which in turn leads to the upregulation of TRIM6 via an unknown mechanism.