Research Paper Volume 11, Issue 11 pp 3601—3623

Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma

Figure 2. Hub genes identification. (A) Genes with a combined weight score > 0.2 in brown module were taken as hub genes in the co-expression network (B) Protein–protein interaction network of genes in the brown module. The color intensity in each node was proportional to the degree of connectivity in the network. (C) Selection of common hub genes in co-expression network and PPI network. (D) Survival analysis showed that RHCG exhibited the significant prognostic value for HNSCC patients.