Research Paper Volume 11, Issue 11 pp 3601—3623

Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma

Figure 7. Hypermethylation of RHCG promoter region lead to downregulation of RHCG. (A) Comparison of methylation level of RHCG in HNSCC samples and normal tissues based on MethHC database. (B) Correlation between RHCG expression and RHCG promoter methylation according to MethHC database. (C) Correlation between RHCG expression and RHCG methylation in the present cohort of 299 HNSCC patients. (DH) Correlation between RHCG expression and five methylation sites in RHCG promoter region of 299 HNSCC patients. (IJ) Survival curves of 299 HNSCC patients stratified by RHCG methylation level (I) and RHCG methylation and expression level (J).