Research Paper Volume 11, Issue 11 pp 3639—3649

MORC2 promotes cell growth and metastasis in human cholangiocarcinoma and is negatively regulated by miR-186-5p

Figure 4. Knockdown of MORC2 inhibits tumor growth and liver metastasis in vivo. (AC) Knockdown of MORC2 expression significantly inhibited CCA cell growth in nude mice, and the tumor weight (B) and tumor volume (C) were significantly reduced in the sh-MORC2 group compared to those in the sh-NC group. (D) Knockdown of MORC2 significantly reduced Ki-67 expression in vivo. (E) An experimental metastasis animal model was constructed by injecting MORC2 stable knockdown HuCCT1 cells into the distal tip of the spleen (Left). Representative images from each group are shown (Right). (F) The number of tumor nodules on the liver surfaces from the two groups is shown. **P < 0.01.