Research Paper Volume 11, Issue 11 pp 3795—3810

Kainic acid Induces production and aggregation of amyloid β-protein and memory deficits by activating inflammasomes in NLRP3- and NF-κB-stimulated pathways

Figure 1. KA augments the activity of inflammasome in vivo and in vitro. (A and B) Phosphorylation levels of NF-κB and expression levels of NLRP3, IL-1β, and BDNF in KA-treated mice brains at different time points (N=6). (C and D) Phosphorylation levels of NF-κB and expression levels of NLRP3, IL-1β, and BDNF in KA-treated BV2 cells at different concentrations (N=3). (E and F) Phosphorylation levels of NF-κB and expression levels of NLRP3, IL-1β, and BDNF in KA-treated BV2 cells at different time points (N=3). The optical density of bands in Western blotting was analyzed by ImageJ software *P<0.05, **P<0.01, and ***P<0.001 vs the controls; the significant difference from the respective values were determined by the one-way analysis of variance test.