Research Paper Volume 11, Issue 11 pp 3795—3810

Kainic acid Induces production and aggregation of amyloid β-protein and memory deficits by activating inflammasomes in NLRP3- and NF-κB-stimulated pathways

Figure 6. Bay11-7082 suppresses KA-induced Aβ in the brains of APP23 mice. (A) The production of Aβ in the brains of KA (10 mg/kg)- and/or Bay11-7082 (1 mg/kg)+KA-treated APP23 mice. (B) Immunohistochemical staining of Aβ in KA and/or Bay11-7082+KA-treated APP23 brains. (C) The visible number of APs in the brains of APP23 mice treated with or without KA and/or Bay11-7082+KA. *P<0.05, ***P<0.001 vs controls; #P<0.05, ##P<0.01 vs the KA group; the significant difference from the respective values were determined by the one-way analysis of variance test; N=6.