Research Paper Volume 11, Issue 11 pp 3795—3810

Kainic acid Induces production and aggregation of amyloid β-protein and memory deficits by activating inflammasomes in NLRP3- and NF-κB-stimulated pathways

Figure 7. Bay11-7082 mitigates KA-induced memory deficits using the Morris water maze test. (A and B) During the first 2 days of visible platform tests, the KA and Bay11-7082 treated and control APP23 mice exhibited a similar latency to escape onto the visible platform. P>0.05 by Student’s t-test. (C and D) In the hidden platform tests, KA-treated APP23 mice showed a longer latency and length to escape onto the hidden platform on the third and fourth days, which was ameliorated by the addition of Bay11-7082 on the fourth day. *P<0.05; ***P<0.001 vs the control group; ##P<0.01; ###P<0.001 vs the KA-treated group by ANOVA. (E) In the probe trial on the seventh day, the KA-treated APP23 mice traveled into the third quadrant, where the hidden platform was previously placed, significantly fewer times than the controls, which were improved by the Bay11-7082 treatment. *P<0.05 vs the control group; #P<0.05 vs the KA-treated group by ANOVA; N=6.