Research Paper Volume 11, Issue 11 pp 3811—3823

Long non-coding RNA AGAP2-AS1 exerts oncogenic properties in glioblastoma by epigenetically silencing TFPI2 through EZH2 and LSD1

Figure 6. Silencing of AGAP2-AS1 suppresses GBM growth in vivo. U87/MG cells stably transfected with sh-NC or sh-AGAP2-AS1 were inoculated into nude mice (n=6). (A) Tumor volumes were monitored from the seventh day after cell injection. (B and C) At day 27 after cell inoculation, the tumors were removed, photographed and weighed. (D) qRT-PCR analysis of AGAP2-AS1 expression in tumors. (E) Western blot analysis of TFPI2 expression in tumors. *P < 0.05, **P < 0.01.