Research Paper Volume 11, Issue 13 pp 4338—4353

Targeting HMGB1 by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells

Figure 7. BM-MSCs and bone marrow supernatant were isolated from bone marrow of healthy donors and SLE patients. SLE bone marrow supernatant led MSCs to senescence via HMGB1/TLR4/NF-κB signaling pathway, HMGB1 had great significance. Ethyl pyruvate (EP), a high security HMGB1 inhibitor, was injected intraperitoneally to treat MRL/lpr mice aged 14 weeks for 8 weeks. EP alleviated the clinical aspects of lupus nephritis and prolonged survival of MRL/lpr mice, by reversing the senescent phenotype of BM-MSCs from MRL/lpr mice.