Research Paper Volume 11, Issue 13 pp 4382—4406

Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury

Figure 5. Altered cell proliferation and p53 expression after C5a exposure in RTEC. (A) MTT assay of RTEC in logarithmic growth phase treated with the same dosage of C5a showed an inhibition of cell proliferation. (B) TP53 gene expression level in C5a stimulated RTEC. Data are expressed as the mean ± SD (*p< 0.05 versus basal condition).