Withdrawal Notice

This paper was originally published in Aging Advance Online Publications on July 4, 2019.

In compliance with Aging's withdrawal policy, the paper was withdrawn in its entirety. It will not appear in Aging internal or any external indexes or archives.

Long non-coding RNA LINC00265 promotes inflammation via sponging miR-let-7a in abdominal aortic aneurysm

Figure 1. Three deregulated lncRNAs were identified by integrated analysis of AAA expression datasets. (A) The flowchart of the integrated analysis and functional validation. In silico bioinformatics data analysis pipeline consists of curation of four publically available datasets, data preprocessing, and integrated analysis, dataset validation, validation for diagnostic/prognostic values, KEGG pathway and target gene validation, and in vitro and in vivo functional validation. (B) Hierarchical clustering analysis of differentially expressed lncRNAs (fold change>1; P<0.05) in AAA and NAT in GSE7084a dataset. (C) Hierarchical clustering analysis of differentially expressed lncRNAs (fold change>1; P<0.05) in AAA and NAT in GSE7084b dataset. (D) Hierarchical clustering analysis of differentially expressed lncRNAs (fold change>1; P<0.05) in AAA and NAT in GSE47472 dataset. (E) Hierarchical clustering analysis of differentially expressed lncRNAs (fold change>1; P<0.05) in AAA and NAT in GSE57691 dataset. (F) Log FC heatmap of each expression microarray, the abscissa represent the GEO IDs, the ordinate represents the gene name, the red represents log FC > 0, the green represents log FC < 0 and the value in the box represents the log FC value.