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Withdrawal Notice

This paper was originally published in Aging Advance Online Publications on July 4, 2019.

In compliance with Aging's withdrawal policy, the paper was withdrawn in its entirety. It will not appear in Aging internal or any external indexes or archives.

Long non-coding RNA LINC00265 promotes inflammation via sponging miR-let-7a in abdominal aortic aneurysm

Relative expression of LINC00265, let-7a and IL-6 in AAA andApoE−/− AAA model mice. (A) qRT-PCR was performed to detect relative LINC00265 expression in AAA tissues and NAT. Each circle and block represents an individual subject. n=25 for each group. (B) Aortic full-length visualdiagram. (C) Male ApoE−/− mice were infused with Ang II (1000 ng/kg/min) for 28 days to induce AAA. Relative LINC00265 expression was significantly upregulated in the abdominal aortas from Ang II treated mice at days 14 and 28 compared with mice that received an equal volume of NS. N = 5 for each time point. (D) IL-6 mRNA and protein levels are shown for the AAA tissues and NAT. Each circle and block represents an individual subject. n=25 for each group. (E) Scatter plots showing the inverse association between let-7a and IL-6 mRNA levels. Each circle represents an individual subject. AAA: abdominal aortic aneurysm; NAT: normal aortic tissue. *P P

Figure 3. Relative expression of LINC00265, let-7a and IL-6 in AAA andApoE−/− AAA model mice. (A) qRT-PCR was performed to detect relative LINC00265 expression in AAA tissues and NAT. Each circle and block represents an individual subject. n=25 for each group. (B) Aortic full-length visualdiagram. (C) Male ApoE−/− mice were infused with Ang II (1000 ng/kg/min) for 28 days to induce AAA. Relative LINC00265 expression was significantly upregulated in the abdominal aortas from Ang II treated mice at days 14 and 28 compared with mice that received an equal volume of NS. N = 5 for each time point. (D) IL-6 mRNA and protein levels are shown for the AAA tissues and NAT. Each circle and block represents an individual subject. n=25 for each group. (E) Scatter plots showing the inverse association between let-7a and IL-6 mRNA levels. Each circle represents an individual subject. AAA: abdominal aortic aneurysm; NAT: normal aortic tissue. *P < 0.05, **P < 0.01.