Figure 5. Contribution of β2-AR to norepinephrine-induced vasoreactivity in isolated coronary arterioles. Relaxation to NE was significantly impaired in OC animals compared to YC and O+SVF groups at all concentrations (A). NE with CPG20712A, a β1-AR antagonist, attenuated (^) the majority of the vasodilation response (3e-7 – 1e-4 [M]) in YC and O+BM treated groups (B). P≤0.05 vs Young Control (*), vs Old Control (#), vs Old+SVF ($), and pre- vs post-inhibition (^); data are presented as means±SEM and analyzed with two-way repeated measures ANOVA, paired for inhibitor analysis, followed by post-hoc Bonferroni test.